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胱天蛋白酶10

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胱天蛋白酶10
識別號
別名CASP10;, ALPS2, FLICE2, MCH4, Caspase 10, FLICE-2
外部IDOMIM601762 HomoloGene50038 GeneCardsCASP10
相關疾病
autoimmune lymphoproliferative syndrome type 2A、​非霍奇金氏淋巴瘤[1]
為以下藥物的標靶
emricasan[2]
基因位置(人類
2號染色體
染色體2號染色體[3]
2號染色體
胱天蛋白酶10的基因位置
胱天蛋白酶10的基因位置
基因座2q33.1起始201,182,872 bp[3]
終止201,229,428 bp[3]
RNA表達模式




查閱更多表達數據
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

無數據

蛋白序列

無數據

基因位置​(UCSC)Chr 2: 201.18 – 201.23 Mb無數據
PubMed​查找[4]無數據
維基數據
檢視/編輯人類

胱天蛋白酶10英語:Caspase 10)是一種在人類中由CASP10基因編碼的[5]

該基因編碼的蛋白質是胱天蛋白酶家族的成員。胱天蛋白酶的連續活化在細胞凋亡的執行階段發揮着核心作用。胱天蛋白酶以無活性的酶原形式存在,在保守的天冬氨酸殘基處經歷蛋白水解加工,產生一大一小兩個亞基,然後二聚化形成活性酶。

胱天蛋白酶9裂解並活化胱天蛋白酶37,而該酶本身由胱天蛋白酶8加工。該基因的突變與II型自體免疫性淋巴細胞增生綜合症中出現的細胞凋亡缺陷相關。該基因有三種編碼不同異構體的選擇性剪接的轉錄變體。[6]

相互作用

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胱天蛋白酶10已被證明可以與以下物質相互作用

參見

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參考文獻

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  1. ^ 與胱天蛋白酶10相關的疾病;在維基數據上查看/編輯參考. 
  2. ^ 對Caspase 10起作用的藥物;在維基數據上查看/編輯參考. 
  3. ^ 3.0 3.1 3.2 GRCh38: Ensembl release 89: ENSG00000003400 - Ensembl, May 2017
  4. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Fernandes-Alnemri T, Armstrong RC, Krebs J, Srinivasula SM, Wang L, Bullrich F, Fritz LC, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc Natl Acad Sci USA. October 1996, 93 (15): 7464–9. Bibcode:1996PNAS...93.7464F. PMC 38767可免費查閱. PMID 8755496. doi:10.1073/pnas.93.15.7464可免費查閱. 
  6. ^ Entrez Gene: CASP10 caspase 10, apoptosis-related cysteine peptidase. 
  7. ^ 7.0 7.1 7.2 Vincenz, C; Dixit V M. Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling. J. Biol. Chem. (UNITED STATES). March 1997, 272 (10): 6578–83. ISSN 0021-9258. PMID 9045686. doi:10.1074/jbc.272.10.6578可免費查閱. 
  8. ^ 8.0 8.1 Srinivasula SM, Ahmad M, Ottilie S, Bullrich F, Banks S, Wang Y, Fernandes-Alnemri T, Croce CM, Litwack G, Tomaselli KJ, Armstrong RC, Alnemri ES. FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. J. Biol. Chem. (UNITED STATES). July 1997, 272 (30): 18542–5. ISSN 0021-9258. PMID 9228018. doi:10.1074/jbc.272.30.18542可免費查閱. 
  9. ^ Wang, J; Chun H J; Wong W; Spencer D M; Lenardo M J. Caspase-10 is an initiator caspase in death receptor signaling. Proc. Natl. Acad. Sci. U.S.A. (United States). November 2001, 98 (24): 13884–8. Bibcode:2001PNAS...9813884W. ISSN 0027-8424. PMC 61136可免費查閱. PMID 11717445. doi:10.1073/pnas.241358198可免費查閱. 
  10. ^ Micheau, Olivier; Tschopp Jürg. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell (United States). July 2003, 114 (2): 181–90. ISSN 0092-8674. PMID 12887920. doi:10.1016/S0092-8674(03)00521-X可免費查閱. 
  11. ^ Goltsev, Y V; Kovalenko A V; Arnold E; Varfolomeev E E; Brodianskii V M; Wallach D. CASH, a novel caspase homologue with death effector domains. J. Biol. Chem. (UNITED STATES). August 1997, 272 (32): 19641–4. ISSN 0021-9258. PMID 9289491. doi:10.1074/jbc.272.32.19641可免費查閱. 
  12. ^ 12.0 12.1 12.2 12.3 Gajate, Consuelo; Mollinedo Faustino. Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy. J. Biol. Chem. (United States). March 2005, 280 (12): 11641–7. ISSN 0021-9258. PMID 15659383. doi:10.1074/jbc.M411781200可免費查閱. 
  13. ^ Guo, Yin; Srinivasula Srinivasa M; Druilhe Anne; Fernandes-Alnemri Teresa; Alnemri Emad S. Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. J. Biol. Chem. (United States). April 2002, 277 (16): 13430–7. ISSN 0021-9258. PMID 11832478. doi:10.1074/jbc.M108029200可免費查閱. 
  14. ^ Srinivasula, S M; Ahmad M; Fernandes-Alnemri T; Litwack G; Alnemri E S. Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). December 1996, 93 (25): 14486–91. Bibcode:1996PNAS...9314486S. ISSN 0027-8424. PMC 26159可免費查閱. PMID 8962078. doi:10.1073/pnas.93.25.14486可免費查閱. 
  15. ^ 15.0 15.1 MacFarlane, M; Ahmad M; Srinivasula S M; Fernandes-Alnemri T; Cohen G M; Alnemri E S. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J. Biol. Chem. (UNITED STATES). October 1997, 272 (41): 25417–20. ISSN 0021-9258. PMID 9325248. doi:10.1074/jbc.272.41.25417可免費查閱. 
  16. ^ Zheng, L; Schickling O; Peter M E; Lenardo M J. The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm. J. Biol. Chem. (United States). August 2001, 276 (34): 31945–52. ISSN 0021-9258. PMID 11395500. doi:10.1074/jbc.M102799200可免費查閱. 

拓展閱讀

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外部連結

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