钙蛋白酶9

钙蛋白酶9
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1ZIV、2P0R
識別號
别名	CAPN9；, GC36, nCL-4, calpain 9
外部ID	OMIM：606401 MGI：1920897 HomoloGene：38208 GeneCards：CAPN9
相關疾病
	近視
基因位置（人类）
染色体	1號染色體
终止	230,802,003 bp
基因位置（小鼠）
染色体	小鼠8号染色体
终止	125,345,470 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本體
分子功能	• calcium ion binding; • 肽酶活性; • 半胱氨酸型肽酶活性; • 水解酶活性; • 金屬離子結合; • calcium-dependent cysteine-type endopeptidase activity;
細胞組分	• 胞內; • 細胞質; • 细胞组件;
生物學過程	• 消化作用; • 蛋白酶解; • sarcomere organization;
	Sources:Amigo / QuickGO
直系同源
	10753
	73647
	ENSG00000135773
	ENSMUSG00000031981
	O14815
	Q9D805
	NM_006615; NM_016452; NM_001319676
	NM_023709
	NP_001306605; NP_006606; NP_057536
	NP_076198
	維基數據
檢視/編輯人類	檢視/編輯小鼠

钙蛋白酶9（英语：Calpain-9）是一种在人类中由CAPN9基因编码的蛋白质。^[6]^[7]^[8]

钙蛋白酶是普遍存在的、保守的钙依赖性半胱氨酸蛋白酶家族。钙蛋白酶是由不变的小亚基和可变的大亚基组成的异二聚体。大亚基具有半胱氨酸蛋白酶结构域，而两个亚基都具有钙结合结构域。钙蛋白酶与神经退行性过程有关，因为它们的激活可以由钙流入和氧化应激触发。由该基因编码的蛋白质主要在胃和小肠中表达，并可能在消化道中具有特殊功能。该基因被认为与胃癌有关。该基因可编码不同亚型的多个可变剪接转录物变体。^[8]

参考资料[编辑]

^ 與钙蛋白酶9相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000135773 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000031981 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lee HJ, Sorimachi H, Jeong SY, Ishiura S, Suzuki K. Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract. Biol Chem. May 1998, 379 (2): 175–184. PMID 9524069. S2CID 37483841. doi:10.1515/bchm.1998.379.2.175.
^ Yoshikawa Y, Mukai H, Hino F, Asada K, Kato I. Isolation of two novel genes, down-regulated in gastric cancer. Jpn J Cancer Res. Jul 2000, 91 (5): 459–63. PMC 5926377 . PMID 10835488. doi:10.1111/j.1349-7006.2000.tb00967.x.
^ ^8.0 ^8.1 Entrez Gene: CAPN9 calpain 9. [2023-01-28]. （原始内容存档于2010-12-05）.

延伸阅读[编辑]

Huang Y, Wang KK. The calpain family and human disease. Trends in Molecular Medicine. 2001, 7 (8): 355–362. PMID 11516996. doi:10.1016/S1471-4914(01)02049-4.
Suzuki K, Sorimachi H, Yoshizawa T, et al. Calpain: novel family members, activation, and physiologic function. Biol. Chem. Hoppe-Seyler. 1996, 376 (9): 523–9. PMID 8561910. doi:10.1515/bchm3.1995.376.9.523.
Davis TL, Walker JR, Finerty PJ, et al. The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. J. Mol. Biol. 2007, 366 (1): 216–229. PMID 17157313. doi:10.1016/j.jmb.2006.11.037.
Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
Lee HJ, Tomioka S, Kinbara K, et al. Characterization of a human digestive tract-specific calpain, nCL-4, expressed in the baculovirus system. Arch. Biochem. Biophys. 1999, 362 (1): 22–31. PMID 9917325. doi:10.1006/abbi.1998.1021.

外部链接[编辑]

Human CAPN9 genome location and CAPN9 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.
The MEROPS online database for peptidases and their inhibitors: C02.006
PDB中UniProt可用的所有結構信息之概述：O14815 (Human Calpain-9 (CAPN9)) 在PDBe-KB（英语：PDBe-KB）。

[1] 與钙蛋白酶9相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000135773 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000031981 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9524069-6] Lee HJ, Sorimachi H, Jeong SY, Ishiura S, Suzuki K. Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract. Biol Chem. May 1998, 379 (2): 175–184. PMID 9524069. S2CID 37483841. doi:10.1515/bchm.1998.379.2.175.

[pmid10835488-7] Yoshikawa Y, Mukai H, Hino F, Asada K, Kato I. Isolation of two novel genes, down-regulated in gastric cancer. Jpn J Cancer Res. Jul 2000, 91 (5): 459–63. PMC 5926377 . PMID 10835488. doi:10.1111/j.1349-7006.2000.tb00967.x.

[entrez-8] 8.0 ^8.1 Entrez Gene: CAPN9 calpain 9. [2023-01-28]. （原始内容存档于2010-12-05）.

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