組織蛋白酶F

組織蛋白酶F
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1M6D
識別號
別名	CTSF；, CATSF, CLN13, cathepsin F
外部ID	OMIM：603539 MGI：1861434 HomoloGene：31194 GeneCards：CTSF
相關疾病
	neuronal ceroid lipofuscinosis 13、adult neuronal ceroid lipofuscinosis
基因位置（人類）
染色體	11號染色體
終止	66,568,879 bp
基因位置（小鼠）
染色體	小鼠19號染色體
終止	4,910,946 bp
RNA表達模式
	查閱更多表達數據
基因本體
分子功能	• 肽酶活性; • 半胱氨酸型肽酶活性; • 水解酶活性; • cysteine-type endopeptidase activity;
細胞組分	• 細胞外囊泡; • 溶酶體; • lysosomal lumen; • 外排體; • 細胞外空間; • collagen-containing extracellular matrix;
生物學過程	• proteolysis involved in cellular protein catabolic process; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • 蛋白酶解;
	Sources:Amigo / QuickGO
直系同源
	8722
	56464
	ENSG00000174080
	ENSMUSG00000083282
	Q9UBX1
	Q9R013
	NM_003793
	NM_019861
	NP_003784
	NP_063914
	維基數據
檢視/編輯人類	檢視/編輯小鼠

組織蛋白酶F（英文：Cathepsin F）是一種在人體中由CTSF基因編碼的蛋白質。^[6]^[7]^[8]

木瓜樣蛋白酶是半胱氨酸蛋白酶家族，代表溶酶體蛋白水解系統的主要成分。通常，組織蛋白酶包含一個信號肽，然後是一個前肽，再然後是一個催化活性成熟區。組織蛋白酶F前體非常長的（251個氨基酸殘基）前區包含一個與組織蛋白酶L樣酶的前段相似的C端結構域、一個50個殘基的柔性連接肽和N端結構域預計採用胱抑素樣摺疊組織蛋白酶F前區在木瓜蛋白酶家族半胱氨酸蛋白酶中是獨一無二的，因為它包含這個額外的N端片段，預計與胱抑素超家族的半胱氨酸蛋白酶抑制劑具有結構相似性。這種胱抑素樣結構域包含一些已知對抑制活性很重要的元素。CTSF編碼預測的484個氨基酸的蛋白質，其中包含19個殘基信號肽。組織蛋白酶F含有五個潛在的N-連接糖基化位點，它可能通過甘露糖6-磷酸受體途徑靶向內體/溶酶體區室。組織蛋白酶F基因普遍表達，它定位於染色體11q13，接近編碼組織蛋白酶W的基因。^[8]

泰國肝吸蟲的免疫診斷[編輯]

組織蛋白酶F可用作測試泰國肝吸蟲造成的疾病的替代方法。^[9]近年來，泰國肝吸蟲的診斷一直通過大便檢查來完成，被認為是「金標準」方法。然而，基於糞便的診斷可能是不可靠的^[10]，儘管它是一種非侵入性方法。進行的實驗表明，通過使用重組DNA技術和組織蛋白酶F半胱氨酸蛋白酶，可以產生更可靠的結果。

組織蛋白酶F在蝦夷盤扇貝中的表達[編輯]

最近的實驗表明在蝦夷盤扇貝中發現了組織蛋白酶F。^[11]在蝦夷盤扇貝的各個胚胎發育階段鑑定組織蛋白酶F基因具有重要意義。組織蛋白酶F基因在先天免疫反應中具有重要作用。蝦夷盤扇貝一直因細菌性疾病而遭受高死亡率。組織蛋白酶F的發現可以領導進一步的研究和解決蝦夷盤扇貝死亡率問題的方法。

參考文獻[編輯]

^ 與组织蛋白酶F相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000174080 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000083282 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang B, Shi GP, Yao PM, Li Z, Chapman HA, Bromme D. Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization. J Biol Chem. Dec 1998, 273 (48): 32000–8. PMID 9822672. doi:10.1074/jbc.273.48.32000 .
^ Santamaria I, Velasco G, Pendas AM, Paz A, Lopez-Otin C. Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain. J Biol Chem. Jun 1999, 274 (20): 13800–9. PMID 10318784. doi:10.1074/jbc.274.20.13800 .
^ ^8.0 ^8.1 Entrez Gene: CTSF cathepsin F.
^ Teimoori, Salma; Arimatsu, Yuji; Laha, Thewarach; Kaewkes, Sasithorn; Sereerak, Piya; Tangkawattana, Sirikachorn; Brindley, Paul J; Sripa, Banchob. Immunodiagnosis of opisthorchiasis using parasite cathepsin F. Parasitology Research. December 2015, 114 (12): 4571–4578. ISSN 0932-0113. PMC 4917378 . PMID 26344868. doi:10.1007/s00436-015-4703-9 （英語）.
^ Korkmaz, Huseyin; Findik, Duygu; Ugurluoglu, Ceyha; Terzi, Yuksel. Reliability of stool antigen tests: investigation of the diagnostic value of a new immunochromatographic Helicobacter pylori approach in dyspeptic patients. Asian Pacific Journal of Cancer Prevention. 2015, 16 (2): 657–660. ISSN 2476-762X. PMID 25684503. doi:10.7314/apjcp.2015.16.2.657 .
^ Guo, Haobing; Li, Yangping; Zhang, Meiwei; Li, Ruojiao; Li, Wanru; Lou, Jiarun; Bao, Zhenmin; Wang, Yangfan. Expression of Cathepsin F in response to bacterial challenges in Yesso scallop Patinopecten yessoensis. Fish & Shellfish Immunology. September 2018, 80: 141–147 [2022-10-27]. PMID 29879509. S2CID 47014597. doi:10.1016/j.fsi.2018.06.005. （原始內容存檔於2022-08-06）（英語）.

拓展閱讀[編輯]

Nägler DK, Sulea T, Ménard R. Full-length cDNA of human cathepsin F predicts the presence of a cystatin domain at the N-terminus of the cysteine protease zymogen.. Biochem. Biophys. Res. Commun. 1999, 257 (2): 313–8. PMID 10198209. doi:10.1006/bbrc.1999.0461.
Wex T, Levy B, Wex H, Brömme D. Human cathepsins F and W: A new subgroup of cathepsins.. Biochem. Biophys. Res. Commun. 1999, 259 (2): 401–7. PMID 10362521. doi:10.1006/bbrc.1999.0700.
Wex T, Wex H, Brömme D. The human cathepsin F gene--a fusion product between an ancestral cathepsin and cystatin gene.. Biol. Chem. 2000, 380 (12): 1439–42. PMID 10661872. S2CID 28469574. doi:10.1515/BC.1999.185.
Shi GP, Bryant RA, Riese R, et al. Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages.. J. Exp. Med. 2000, 191 (7): 1177–86. PMC 2193169 . PMID 10748235. doi:10.1084/jem.191.7.1177.
Deussing J, Tisljar K, Papazoglou A, Peters C. Mouse cathepsin F: cDNA cloning, genomic organization and chromosomal assignment of the gene.. Gene. 2000, 251 (2): 165–73. PMID 10876093. doi:10.1016/S0378-1119(00)00196-7.
Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
Oörni K, Sneck M, Brömme D, et al. Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro.. J. Biol. Chem. 2004, 279 (33): 34776–84. PMID 15184381. doi:10.1074/jbc.M310814200 .
Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Vazquez-Ortiz G, Pina-Sanchez P, Vazquez K, et al. Overexpression of cathepsin F, matrix metalloproteinases 11 and 12 in cervical cancer.. BMC Cancer. 2006, 5 (1): 68. PMC 1175083 . PMID 15989693. doi:10.1186/1471-2407-5-68.
Kaakinen R, Lindstedt KA, Sneck M, et al. Angiotensin II increases expression and secretion of cathepsin F in cultured human monocyte-derived macrophages: an angiotensin II type 2 receptor-mediated effect.. Atherosclerosis. 2007, 192 (2): 323–7. PMID 16963053. doi:10.1016/j.atherosclerosis.2006.08.001.

外部連結[編輯]

The MEROPS online database for peptidases and their inhibitors: C01.018

[1] 與组织蛋白酶F相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000174080 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000083282 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9822672-6] Wang B, Shi GP, Yao PM, Li Z, Chapman HA, Bromme D. Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization. J Biol Chem. Dec 1998, 273 (48): 32000–8. PMID 9822672. doi:10.1074/jbc.273.48.32000 .

[pmid10318784-7] Santamaria I, Velasco G, Pendas AM, Paz A, Lopez-Otin C. Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain. J Biol Chem. Jun 1999, 274 (20): 13800–9. PMID 10318784. doi:10.1074/jbc.274.20.13800 .

[entrez-8] 8.0 ^8.1 Entrez Gene: CTSF cathepsin F.

[9] Teimoori, Salma; Arimatsu, Yuji; Laha, Thewarach; Kaewkes, Sasithorn; Sereerak, Piya; Tangkawattana, Sirikachorn; Brindley, Paul J; Sripa, Banchob. Immunodiagnosis of opisthorchiasis using parasite cathepsin F. Parasitology Research. December 2015, 114 (12): 4571–4578. ISSN 0932-0113. PMC 4917378 . PMID 26344868. doi:10.1007/s00436-015-4703-9 （英語）.

[10] Korkmaz, Huseyin; Findik, Duygu; Ugurluoglu, Ceyha; Terzi, Yuksel. Reliability of stool antigen tests: investigation of the diagnostic value of a new immunochromatographic Helicobacter pylori approach in dyspeptic patients. Asian Pacific Journal of Cancer Prevention. 2015, 16 (2): 657–660. ISSN 2476-762X. PMID 25684503. doi:10.7314/apjcp.2015.16.2.657 .

[11] Guo, Haobing; Li, Yangping; Zhang, Meiwei; Li, Ruojiao; Li, Wanru; Lou, Jiarun; Bao, Zhenmin; Wang, Yangfan. Expression of Cathepsin F in response to bacterial challenges in Yesso scallop Patinopecten yessoensis. Fish & Shellfish Immunology. September 2018, 80: 141–147 [2022-10-27]. PMID 29879509. S2CID 47014597. doi:10.1016/j.fsi.2018.06.005. （原始內容存檔於2022-08-06）（英語）.

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