1-甲基-4-(2-肼基乙基)哌嗪

1-甲基-4-(2-肼基乙基)哌嗪
識別
CAS號	13562-46-4
SMILES	NNCCN1CCN(C)CC1;
性質
化學式	C7H18N4
摩爾質量	158.24 g·mol−1
沸點	74~75 °C（0.15 mmHg）
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

1-甲基-4-(2-肼基乙基)哌嗪是一種有機化合物，化學式為C₇H₁₈N₄。它可以從塞卡替尼（英語：Saracatinib）合成過程中Mitsunobu反應的副產物[2-(4-甲基哌嗪基)乙基]肼-1,2-二甲酸二叔丁酯的水解反應製得。^[2]它和2,4-二氯-N-(2,6-二氯苯基)-5-嘧啶甲酰胺反應，可以得到2-氯-N-(2,6-二氯苯基)-4-{1-[2-(4-甲基哌嗪基)乙基]肼基]5-嘧啶甲酰胺。^[3]

參考文獻[編輯]

^ Biel, John H.; Hoya, Wallace K. Unsymmetrical disubstituted aminoalkyl hydrazines. 1966. US3272807.
^ J. Gair Ford, Simon M. Pointon, Lyn Powell, Paul S. Siedlecki, John Baum, Richard Chubb, Robin Fieldhouse, James Muxworthy, Alex Nivlet, Rachel Stenson, and Eleanor Warwick. Process Research and Development for the Kilogram Manufacture of the SRC Kinase Inhibitor AZD0530. Org. Process Res. Dev. 2010, 14, 5, 1078–1087. doi:10.1021/op100161y.
^ David J. Kopecky; et al. Identification and optimization of N³,N⁶-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors. Bioorganic & Medicinal Chemistry Letters, 2008. 18 (24): 6352-6356. doi:10.1016/j.bmcl.2008.10.092.

[1] Biel, John H.; Hoya, Wallace K. Unsymmetrical disubstituted aminoalkyl hydrazines. 1966. US3272807.

[2] J. Gair Ford, Simon M. Pointon, Lyn Powell, Paul S. Siedlecki, John Baum, Richard Chubb, Robin Fieldhouse, James Muxworthy, Alex Nivlet, Rachel Stenson, and Eleanor Warwick. Process Research and Development for the Kilogram Manufacture of the SRC Kinase Inhibitor AZD0530. Org. Process Res. Dev. 2010, 14, 5, 1078–1087. doi:10.1021/op100161y.

[3] David J. Kopecky; et al. Identification and optimization of N³,N⁶-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors. Bioorganic & Medicinal Chemistry Letters, 2008. 18 (24): 6352-6356. doi:10.1016/j.bmcl.2008.10.092.

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