1-甲基-4-(2-肼基乙基)哌嗪

1-甲基-4-(2-肼基乙基)哌嗪
识别
CAS号	13562-46-4
SMILES	NNCCN1CCN(C)CC1;
性质
化学式	C7H18N4
摩尔质量	158.24 g·mol−1
沸点	74~75 °C（0.15 mmHg）
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

1-甲基-4-(2-肼基乙基)哌嗪是一种有机化合物，化学式为C₇H₁₈N₄。它可以从塞卡替尼（英语：Saracatinib）合成过程中Mitsunobu反应的副产物[2-(4-甲基哌嗪基)乙基]肼-1,2-二甲酸二叔丁酯的水解反应制得。^[2]它和2,4-二氯-N-(2,6-二氯苯基)-5-嘧啶甲酰胺反应，可以得到2-氯-N-(2,6-二氯苯基)-4-{1-[2-(4-甲基哌嗪基)乙基]肼基]5-嘧啶甲酰胺。^[3]

参考文献[编辑]

^ Biel, John H.; Hoya, Wallace K. Unsymmetrical disubstituted aminoalkyl hydrazines. 1966. US3272807.
^ J. Gair Ford, Simon M. Pointon, Lyn Powell, Paul S. Siedlecki, John Baum, Richard Chubb, Robin Fieldhouse, James Muxworthy, Alex Nivlet, Rachel Stenson, and Eleanor Warwick. Process Research and Development for the Kilogram Manufacture of the SRC Kinase Inhibitor AZD0530. Org. Process Res. Dev. 2010, 14, 5, 1078–1087. doi:10.1021/op100161y.
^ David J. Kopecky; et al. Identification and optimization of N³,N⁶-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors. Bioorganic & Medicinal Chemistry Letters, 2008. 18 (24): 6352-6356. doi:10.1016/j.bmcl.2008.10.092.

[1] Biel, John H.; Hoya, Wallace K. Unsymmetrical disubstituted aminoalkyl hydrazines. 1966. US3272807.

[2] J. Gair Ford, Simon M. Pointon, Lyn Powell, Paul S. Siedlecki, John Baum, Richard Chubb, Robin Fieldhouse, James Muxworthy, Alex Nivlet, Rachel Stenson, and Eleanor Warwick. Process Research and Development for the Kilogram Manufacture of the SRC Kinase Inhibitor AZD0530. Org. Process Res. Dev. 2010, 14, 5, 1078–1087. doi:10.1021/op100161y.

[3] David J. Kopecky; et al. Identification and optimization of N³,N⁶-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors. Bioorganic & Medicinal Chemistry Letters, 2008. 18 (24): 6352-6356. doi:10.1016/j.bmcl.2008.10.092.

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