PB-22

**PB-22**
法律規範狀態
法律規範	加：Schedule II; 德：Anlage II; 英：Class B; 美：附表I;
识别信息
	IUPAC命名法 1-Pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester; ;
CAS号	1400742-17-7
ChemSpider	29339966;
UNII	QM6J8F29FE;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID70856177 ;
ECHA InfoCard	100.233.114
化学信息
化学式	C23H22N2O2
摩尔质量	358.44 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES CCCCCN1C=C(C2=CC=CC=C21)C(=O)OC3=CC=CC4=C3N=CC=C4;
	InChI InChI=1S/C23H22N2O2/c1-2-3-6-15-25-16-19(18-11-4-5-12-20(18)25)23(26)27-21-13-7-9-17-10-8-14-24-22(17)21/h4-5,7-14,16H,2-3,6,15H2,1H3; Key:ZAVGICCEAOUWFM-UHFFFAOYSA-N;

PB-22是一种狡詐家藥物，化学式为C₂₃H₂₂N₂O₂，它在网络上作为大麻模拟剂供应，并在2013年于日本的合成大麻产品被发现。^[1]^[2]PB-22在其吲哚环的3号位有酯基，可以被视作一类具有独特结构的合成大麻素。它在2014年于新西兰^[3]、同年于美国管控。^[4]^[5]

参考文献[编辑]

^ Uchiyama N, Matsuda S, Kawamura M, Kikura-Hanajiri R, Goda Y. Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative α-PVT and an opioid receptor agonist AH-7921 identified in illegal products. Forensic Toxicology. 2013, 31 (2): 223–240. S2CID 1279637. doi:10.1007/s11419-013-0182-9.
^ Lin M, Ellis B, Eubanks LM, Janda KD. Pharmacokinetic Approach to Combat the Synthetic Cannabinoid PB-22. ACS Chemical Neuroscience. July 2021, 12 (14): 2573–2579. PMID 34254505. S2CID 235808519. doi:10.1021/acschemneuro.1c00360.
^ Jones N. Legal highs pulled from shelves. New Zealand Herald. New Zealand Media and Entertainment. 1 May 2014 [18 August 2020].
^ Behonick G, Shanks KG, Firchau DJ, Mathur G, Lynch CF, Nashelsky M, et al. Four postmortem case reports with quantitative detection of the synthetic cannabinoid, 5F-PB-22. Journal of Analytical Toxicology. October 2014, 38 (8): 559–562. PMC 4334789 . PMID 24876364. doi:10.1093/jat/bku048.
^ PB-22 and 5F-PB-22 (PDF). DEA, Office of Diversion Control.