酸感应离子信道2基因

酸感应离子信道2基因
識別號
别名	ASIC2；, ACCN, ACCN1, ASIC2a, BNC1, BNaC1, MDEG, hBNaC1, acid sensing ion channel subunit 2
外部ID	OMIM：601784 MGI：1100867 HomoloGene：137202 GeneCards：ASIC2
為以下藥物的標靶
	氢正离子、阿米洛利、nafamostat
基因位置（人类）
染色体	17號染色體
终止	34,174,964 bp
基因位置（小鼠）
染色体	小鼠11号染色体
终止	81,859,283 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• ion gated channel activity; • sodium channel activity; • ion channel activity; • 血浆蛋白结合; • cation channel activity; • ligand-gated sodium channel activity; • acid-sensing ion channel activity;
細胞組分	• integral component of membrane; • 膜; • 细胞膜; • 树突棘; • integral component of plasma membrane; • 突触; • neuronal cell body; • neuron projection;
生物學過程	• 化学性突触传递; • positive regulation of synapse assembly; • peripheral nervous system development; • sodium ion transmembrane transport; • detection of mechanical stimulus involved in sensory perception; • sodium ion transport; • regulation of membrane potential; • regulation of ion transmembrane transport; • response to mechanical stimulus; • negative regulation of apoptotic process; • cation transport; • sensory perception of sound; • sensory perception of sour taste; • ion transport; • cation transmembrane transport; • central nervous system development; • ion transmembrane transport; • regulation of vasoconstriction; • protein localization to synapse; • response to acidic pH; • 光转换; • regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback;
	Sources:Amigo / QuickGO
直系同源
	40
	11418
	ENSG00000108684
	ENSMUSG00000020704
	Q16515
	Q925H0
	NM_183377; NM_001094
	NM_001034013; NM_007384
	NP_001085; NP_899233
	NP_001029185; NP_031410
	維基數據
檢視/編輯人類	檢視/編輯小鼠

酸感应离子信道2 (ASIC2)也称为 氢离子敏感阳离子频道1、神经元 (ACCN1)或 大脑钠通道1 (BNaC1)是一个蛋白质，在人类中的编码的ASIC2 基因. ASIC2基因是五个旁系同源基因编码蛋白质，形成三聚酸感应离子频道 (Asic)在哺乳动物。^[6] CDNA的这种基因第一个克隆在1996年。^[7]^[8]^[9]^[10] ASIC基因可以通过不同的拼接形成不同类型的蛋白质变体。

这些基因主要是在中央和周围神经系统。

可以形成异三聚体渠道。^[11]^[12]

结构和功能[编辑]

这个基因编码的成员ASIC家族的蛋白质。^[13] 其中有许多氨基酸残留与保守的间隔。 TM的区域一般都是象征作为TM1(克隆N端)和TM2(靠近C端).

孔道通过离子选择性地流动，从外面到细胞质形成由三TM2地区的三聚体。^[6]

参考文献[编辑]

^ 對Acid sensing ion channel subunit 2起作用的藥物；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000108684 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000020704 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^6.0 ^6.1 ASIC and ENaC type sodium channels: Conformational states and the structures of the ion selectivity filters (PDF). FEBS Journal. 2017, 284 (4): 525–545 [2019-12-03]. PMID 27580245. doi:10.1111/febs.13840. （原始内容 (PDF)存档于2019-05-02）. 引用错误：带有name属性“2017-Hanukoglu”的<ref>标签用不同内容定义了多次
^ The human degenerin MDEG, an amiloride-sensitive neuronal cation channel, is localized on chromosome 17q11.2-17q12 close to the microsatellite D17S798. Genomics. Oct 1996, 37 (2): 269–70. PMID 8921408. doi:10.1006/geno.1996.0558.
^ Cloning and expression of a novel human brain Na+ channel. The Journal of Biological Chemistry. Apr 1996, 271 (14): 7879–82. PMID 8626462. doi:10.1074/jbc.271.14.7879.
^ The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans. The Journal of Biological Chemistry. May 1996, 271 (18): 10433–6. PMID 8631835. doi:10.1074/jbc.271.18.10433.
^ BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proceedings of the National Academy of Sciences of the United States of America. Feb 1997, 94 (4): 1459–64. PMC 19813 . PMID 9037075. doi:10.1073/pnas.94.4.1459.
^ Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+. The Journal of Biological Chemistry. Sep 2000, 275 (37): 28519–25. PMID 10842183. doi:10.1074/jbc.M004114200.
^ The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties. The Journal of Biological Chemistry. Nov 1997, 272 (46): 28819–22. PMID 9360943. doi:10.1074/jbc.272.46.28819.
^ Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases.. Gene. Jan 2016, 579 (2): 95–132. PMC 4756657 . PMID 26772908. doi:10.1016/j.gene.2015.12.061.

外部链接[编辑]

Human ASIC2 genome location and ASIC2 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.
Human BNC1 genome location and BNC1 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.

[1] 對Acid sensing ion channel subunit 2起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000108684 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000020704 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[2017-Hanukoglu-6] 6.0 ^6.1 ASIC and ENaC type sodium channels: Conformational states and the structures of the ion selectivity filters (PDF). FEBS Journal. 2017, 284 (4): 525–545 [2019-12-03]. PMID 27580245. doi:10.1111/febs.13840. （原始内容 (PDF)存档于2019-05-02）. 引用错误：带有name属性“2017-Hanukoglu”的<ref>标签用不同内容定义了多次

[pmid8921408-7] The human degenerin MDEG, an amiloride-sensitive neuronal cation channel, is localized on chromosome 17q11.2-17q12 close to the microsatellite D17S798. Genomics. Oct 1996, 37 (2): 269–70. PMID 8921408. doi:10.1006/geno.1996.0558.

[8] Cloning and expression of a novel human brain Na+ channel. The Journal of Biological Chemistry. Apr 1996, 271 (14): 7879–82. PMID 8626462. doi:10.1074/jbc.271.14.7879.

[9] The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans. The Journal of Biological Chemistry. May 1996, 271 (18): 10433–6. PMID 8631835. doi:10.1074/jbc.271.18.10433.

[10] BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proceedings of the National Academy of Sciences of the United States of America. Feb 1997, 94 (4): 1459–64. PMC 19813 . PMID 9037075. doi:10.1073/pnas.94.4.1459.

[11] Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+. The Journal of Biological Chemistry. Sep 2000, 275 (37): 28519–25. PMID 10842183. doi:10.1074/jbc.M004114200.

[12] The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties. The Journal of Biological Chemistry. Nov 1997, 272 (46): 28819–22. PMID 9360943. doi:10.1074/jbc.272.46.28819.

[2016-Hanukoglu-13] Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases.. Gene. Jan 2016, 579 (2): 95–132. PMC 4756657 . PMID 26772908. doi:10.1016/j.gene.2015.12.061.

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