周期蛋白依赖性激酶4

周期蛋白依赖性激酶4
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2W96、2W99、2W9F、2W9Z、3G33、5FWL、5FWM、5FWK
識別號
别名	CDK4；, CMM3, PSK-J3, cyclin-dependent kinase 4, cyclin dependent kinase 4
外部ID	OMIM：123829 MGI：88357 HomoloGene：55429 GeneCards：CDK4
相關疾病
	melanoma, cutaneous malignant, susceptibility to, 3、粘膜黑色素瘤
為以下藥物的標靶
	阿伏西地、帕布昔利布
	trilaciclib
基因位置（人类）
染色体	12號染色體
终止	57,756,013 bp
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• 轉移酶活性; • 核苷酸結合; • 蛋白激酶活性; • 激酶活性; • 蛋白质丝氨酸/苏氨酸激酶活性; • 细胞周期蛋白依赖性蛋白丝氨酸/苏氨酸激酶调节剂活性; • 血浆蛋白结合; • ATP結合; • 細胞週期蛋白結合; • 細胞週期蛋白依賴性蛋白絲氨酸/蘇氨酸激酶活性; • 大分子复合物结合;
細胞組分	• 細胞質; • 细胞质基质; • 細胞週期蛋白依賴性蛋白激酶全酶複合物; • 核膜; • 膜; • 轉錄調節複合物; • 双细胞紧密连接; • 核质; • 核仁; • 细胞质的核周区域; • 染色质; • 细胞核; • 細胞週期蛋白D2-CDK4複合物; • 大分子复合体;
生物學過程	• 磷酸化; • response to testosterone; • positive regulation of fibroblast proliferation; • response to hyperoxia; • positive regulation of translation; • regulation of cell cycle; • 細胞分裂; • protein phosphorylation; • lens development in camera-type eye; • regulation of cell population proliferation; • response to lead ion; • 昼夜节律; • animal organ regeneration; • positive regulation of cell population proliferation; • positive regulation of cell size; • positive regulation of apoptotic process; • 基因調節; • 細胞週期; • positive regulation of G2/M transition of mitotic cell cycle; • response to toxic substance; • positive regulation of cell cycle; • 訊息傳遞; • multicellular organism development; • response to organic substance; • cellular response to insulin stimulus; • regulation of multicellular organism growth; • regulation of insulin receptor signaling pathway; • regulation of lipid biosynthetic process; • regulation of lipid catabolic process; • adipose tissue development; • cellular response to lipopolysaccharide; • cellular response to interleukin-4; • cellular response to phorbol 13-acetate 12-myristate; • cellular response to ionomycin; • transcription initiation from RNA polymerase II promoter; • G1/S transition of mitotic cell cycle; • regulation of cyclin-dependent protein serine/threonine kinase activity; • negative regulation of G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
直系同源
	1019
	12567
	ENSG00000135446
	无数据
	P11802
	P30285
	NM_052984; NM_000075
	NM_009870; NM_001355005
	NP_000066
	NP_034000; NP_001341934
	維基數據
檢視/編輯人類	檢視/編輯小鼠

周期蛋白依赖性激酶4（英語：cyclin-dependent kinases 4，CDK4）是周期蛋白依赖性激酶家族成員之一，是真核細胞中調控細胞週期的蛋白質。

参考文献

^ 與周期蛋白依赖性激酶4相關的疾病；在維基數據上查看/編輯參考.
^ 對Cyclin dependent kinase 4起作用的藥物；在維基數據上查看/編輯參考.
^ 對Cyclin-dependent kinase 4起作用的藥物；在維基數據上查看/編輯參考.
^ ^4.0 ^4.1 ^4.2 GRCh38: Ensembl release 89: ENSG00000135446 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

外部链接

[1] 與周期蛋白依赖性激酶4相關的疾病；在維基數據上查看/編輯參考.

[2] 對Cyclin dependent kinase 4起作用的藥物；在維基數據上查看/編輯參考.

[3] 對Cyclin-dependent kinase 4起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-4] 4.0 ^4.1 ^4.2 GRCh38: Ensembl release 89: ENSG00000135446 - Ensembl, May 2017

[5] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

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