帕扎克兰

**帕扎克兰**
识别信息
	IUPAC命名法 2-Methyl-3-{[(2S)-pyrrolidin-2-yl]methoxy}pyridine; ;
CAS号	161417-03-4
PubChem CID	178052;
ChemSpider	155000 ;
UNII	CL2002R563;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID20167149 ;
化学信息
化学式	C11H16N2O
摩尔质量	192.26 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES CC1=C(C=CC=N1)OC[C@@H]2CCCN2;
	InChI InChI=1S/C11H16N2O/c1-9-11(5-3-6-12-9)14-8-10-4-2-7-13-10/h3,5-6,10,13H,2,4,7-8H2,1H3/t10-/m0/s1 ; Key:YRVIKLBSVVNSHF-JTQLQIEISA-N ;

帕扎克兰（INN：Pozanicline；开发代号：ABT-089）是一种含氮有机化合物，分子式C₁₁H₁₆N₂O，是美國雅培公司研发的益智藥和神经保护藥。^[1]^[2]^[3]

参考文献[编辑]

^ Lin NH, Gunn DE, Ryther KB, Garvey DS, Donnelly-Roberts DL, Decker MW, et al. Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties. Journal of Medicinal Chemistry. January 1997, 40 (3): 385–90. PMID 9022806. doi:10.1021/jm960233u.
^ Sullivan JP, Donnelly-Roberts D, Briggs CA, Anderson DJ, Gopalakrishnan M, Xue IC, et al. ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties. The Journal of Pharmacology and Experimental Therapeutics. October 1997, 283 (1): 235–46. PMID 9336329.
^ Decker MW, Bannon AW, Curzon P, Gunther KL, Brioni JD, Holladay MW, et al. ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys. The Journal of Pharmacology and Experimental Therapeutics. October 1997, 283 (1): 247–58. PMID 9336330.